Regenerative medicine seeks to replace tissue or organs that have been damaged by disease or trauma. Regenerative medicine seeks to heal and replace issues in the body versus the current clinical strategy that focuses primarily on treating only the symptoms and conditions. Science is revealing the tremendous regeneration potential of our bodies. We don't want to mask the pain, or just manage symptoms. We have entered the age of regenerative medicine we can completely heal our patients. This is an exciting time in history. QCM clinics have the passion and commitment to heal our patients who share this passion and commitment to be healed.
Science is now showing the Medical world that Exosome therapies may offer hope to millions of people who suffer various medical conditions worldwide. Exosome Therapy is the scientific advancement to Stem Cell Therapy.
Exosomes have an endosomal origin and are released by many different cell types, participating in different physiological and/or pathological processes. Depending on their origin, they can alter the fate of recipient cells according to the information transferred.
Extracellular vesicles (EV’s) consist of exosomes and microvesicles, which are released directly from the cell membrane. EV’s can mediate cell–cell communication and are involved in many processes, including immune signaling, angiogenesis, stress response, senescence, proliferation, and cell differentiation. EV’s are involved in restoring tissue and organ damage, and may partially explain the paracrine effects observed in stem cell-based therapeutic approaches. The function and content of EV’s may also harbor information that can be used in tissue engineering, in which paracrine signaling is employed to modulate cell recruitment, differentiation, and proliferation.(1)
Growth factors are proteins that may act locally or systemically to affect the growth of cells in several ways. Various cell activities, including division, are influenced by growth factors. Cytokines are a family of low-molecular-weight proteins that are produced by numerous cell types and are responsible for regulating the immune response, inflammation, tissue remodeling and cellular differentiation. Target cells of growth factors and cytokines are mesenchymal, epithelial and endothelial cells. These molecules frequently have overlapping activities and can act in an autocrine or paracrine fashion. A complex network of growth factors and cytokines guides cellular differentiation and regeneration in all organs and tissues.(2)
Paracrine signaling is a form of cell-to-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling.(3)
(1) Extracellular Vesicles: Potential Roles in Regenerative Medicine
Olivier G. De Jong, Bas W. M. Van Balkom, Raymond M. Schiffelers, Carlijn V. C. Bouten, Marianne C. Verhaar. Front Immunol. 2014; 5: 608.
(2) Effie Ioannidou, “ Therapeutic Modulation of Growth Factors and Cytokines in Regenerative Medicine”, Current Pharmaceutical Design (2006) 12: 2397.
(3) U.S. National Library of Medicine, G04.085.600, Paracrine Communication, Cellular signaling in which a factor secreted by a cell affects other cells in the local environment.
Science has shown that stem cells work by sending out exosomes. Exosomes are how stem cells communicate. There are thousands of studies investigating how Exosomes are creating regeneration in the body reversing a broad range of problems. We create our Amniosomes from Amniotic fluid taken from safely screened donors which are taken only from one donor. They are then brought through a filtered and sterilized to screening all Extra Cellular Vesicles smaller than 120 nm in size. There are no cells remaining so there is no potential of DNA conflict. The fluid in Amniosomes includes exsosome, cytokines, growth factor and mRNA capable of stimulating repair.
An exosome is like a heat-seeking missile fired by a stem cell seeking out areas of inflammation. It has a heavenly payload, which is either a protein that can tell a cell what to do or mRNA, which can stimulate cells to make proteins that the stem cell needs in that area to grow.