Regenerative medicine seeks to replace tissue or organs that have been damaged by disease or trauma. Regenerative medicine seeks to heal and replace issues in the body versus the current clinical strategy that focuses primarily on treating only the symptoms and conditions. Science is revealing the tremendous regeneration potential of our bodies. We don't want to mask the pain, or just manage symptoms. We have entered the age of regenerative medicine we can completely heal our patients. This is an exciting time in history. QCM clinics have the passion and commitment to heal our patients who share this passion and commitment to be healed.
Science is now showing the Medical world that Exosome therapies may offer hope to millions of people who suffer various medical conditions worldwide. Exosome Therapy is the scientific advancement to Stem Cell Therapy.
Exosomes have an endosomal origin and are released by many different cell types, participating in different physiological and/or pathological processes. Depending on their origin, they can alter the fate of recipient cells according to the information transferred.
Extracellular vesicles (EV’s) consist of exosomes and microvesicles, which are released directly from the cell membrane. EV’s can mediate cell–cell communication and are involved in many processes, including immune signaling, angiogenesis, stress response, senescence, proliferation, and cell differentiation. EV’s are involved in restoring tissue and organ damage, and may partially explain the paracrine effects observed in stem cell-based therapeutic approaches. The function and content of EV’s may also harbor information that can be used in tissue engineering, in which paracrine signaling is employed to modulate cell recruitment, differentiation, and proliferation.(1)
Growth factors are proteins that may act locally or systemically to affect the growth of cells in several ways. Various cell activities, including division, are influenced by growth factors. Cytokines are a family of low-molecular-weight proteins that are produced by numerous cell types and are responsible for regulating the immune response, inflammation, tissue remodeling and cellular differentiation. Target cells of growth factors and cytokines are mesenchymal, epithelial and endothelial cells. These molecules frequently have overlapping activities and can act in an autocrine or paracrine fashion. A complex network of growth factors and cytokines guides cellular differentiation and regeneration in all organs and tissues.(2)
Paracrine signaling is a form of cell-to-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling.(3)
(1) Extracellular Vesicles: Potential Roles in Regenerative Medicine
Olivier G. De Jong, Bas W. M. Van Balkom, Raymond M. Schiffelers, Carlijn V. C. Bouten, Marianne C. Verhaar. Front Immunol. 2014; 5: 608.
(2) Effie Ioannidou, “ Therapeutic Modulation of Growth Factors and Cytokines in Regenerative Medicine”, Current Pharmaceutical Design (2006) 12: 2397.
(3) U.S. National Library of Medicine, G04.085.600, Paracrine Communication, Cellular signaling in which a factor secreted by a cell affects other cells in the local environment.
Cells communicate with each other using cytokines. These are proteins that are excreted by one cell and tell another cell what to do. This is one of the ways stem cells work, by orchestrating a repair response through other cells, like a conductor making sure all of the instruments produce beautiful music instead of noise. The Exosomes are the messengers making this happen.
Exosomes derived from stem cells are the promising alternative to cell-based therapy because exosomes avoid most of the problems associated with cell-based therapy while recapitulating the therapeutic efficacy of stem cells. For example, Exosomes have no risk of tumor formation as they cannot replicate. They also can be sterilized by filtration and have a longer shelf-life than cells themselves. So they work longer in the body to promote regeneration. Being much smaller than stem cells, exosomes easily circulate through the body and reach sites of injury. In addition, long-term repetitive administration of exosomes does not elicit toxicity.
Many argue that exosomes may be more important than stem cells due to their unique ability to function as a “messenger” within the body, transferring information from cell to cell. Enhancing or in many cases replacing stem cell therapy with exosomes is considered a superior and optimal therapy. At American Regenerative Medicine, we offer exosome therapy, which contains growth factors, in conjunction with stem cell therapy to enhance healing benefits.
Exosomes are little packets of stuff that bud off the outer wall of the cell. They contain everything from proteins to RNA. However, the really cool thing they can carry is mRNA.
mRNA makes proteins. Think of it as the instruction set for certain proteins and the factory that makes them. These proteins can include everything from building blocks to chemical signals.
When stem cells are being cultured or growing, you find exosomes in the growth media. Harvesting these and injecting them into patients has been proposed as treatment as they can contain both cytokines and mRNA capable of stimulating repair. However, there’s a bit more complexity to this story.
An exosome is like a missile fired by a stem cell toward a target cell. It has a payload, which is either a protein that can tell a cell what to do or mRNA, which can force the other cell to make proteins that the stem cell needs.
Until now, culturing stem cells in the U.S. has not been not permitted. Since the most common way to obtain exosomes is culturing stem cells, exosomes obtained this way have been an unapproved drug product. In addition, if a company tries to isolate exosomes from something like amniotic fluid and makes claims that these can repair tissue, this is also an unapproved drug. However QCM uses Exosomes that have 12 IRB in place and/or in process.
QCM Clinics provide the technology in QRS PEMF resonance, Q-Min Ionic Minerals and Fermented Ginseng and support to cultivate the terrain. In clinical testing, this improves the effectiveness of Exosome therapy by 30-40%.
Introducing a new solution to assist the physician/healthcare provider in the use of minimally manipulated HAF exosomes for patients suffering from osteoarthritis, rheumatoid arthritis, erectile dysfunction, autoimmune conditions, cancer, diabetes, wound, and injury recovery, plus hair loss and cosmetic in their office-based medical practice.
QCM Clinics work the highest advancement in exosomes which have recently obtained IRB approvals for trials of Osteoarthritis of the knee for both targeted injections as well as intravenous use. Our exosome partner has taken the steps to obtain IND approvals from the FDA to conduct phase I/II clinical trials. Because we have a 361 exception status, all of our partner QCM Clinics are protected.
There a several research projects in process related to the use of minimally manipulated HAF exosomes. Cardiovascular conditions such as Acute and Chronic Ischemic Heart Disease, Heart Failure with preserved Ejection Fraction (HFpEF), Pulmonary Hypertension, and Cardiomyopathies (Adult and Pediatric) are being evaluated.
Autoimmune diseases can be beat. Don't accept a pharmaceutical drug approach which only mask some of the symptoms as you progressively decline. Yes it's not easy it does require diet and lifestyle. However modern science is changing the game entirely.
Listen in if you or someone you love is dealing with an autoimmune condition. God designed us to live life and live it abundantly.